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| カタログ番号 | HD593014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ARFIP2 Polyclonal Antibody (HD593014) is a rabbit polyclonal antibody detecting ARFIP2. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARFIP2 (Gly81-Gln341). | ||||||||
| ターゲット | ADP-ribosylation factor-interacting protein 2, ARFIP2, Arfaptin-2, POR1, Partner of RAC1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P53365 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Arfaptin-2 (ARFIP2) is a ~37 kDa protein. Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. 1. Eiseler, T. et al. (2016) The Journal of biological chemistry 291, 462-77. PMID: 26507660 2. Judith, D. et al. (2019) The Journal of cell biology 218, 1634-1652. PMID: 30917996 3. Judith, D. et al. (2019) Autophagy 15, 1660-1661. PMID: 31204568 4. Nguyen, TN. et al. (2021) Molecular cell 81, 2013-2030.e9. PMID: 33773106 5. You, DJ. et al. (2015) Cellular signalling 27, 2173-81. PMID: 26296658 | ||||||||
| 注意事項 | For research use only |
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