Human ARFIP2 Recombinant Protein (N-His) (HD593012)

Name: Human ARFIP2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD593012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD593012
Description	Recombinant Human ARFIP2 Protein, N-His (HD593012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P53365
Protein length	Gly81-Gln341
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADP-ribosylation factor-interacting protein 2, ARFIP2, Arfaptin-2, POR1, Partner of RAC1
Background	Arfaptin-2 is a ~37 kDa protein. Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. 1. Eiseler, T. et al. (2016) The Journal of biological chemistry 291, 462-77. PMID: 26507660 2. Judith, D. et al. (2019) The Journal of cell biology 218, 1634-1652. PMID: 30917996 3. Judith, D. et al. (2019) Autophagy 15, 1660-1661. PMID: 31204568 4. Nguyen, TN. et al. (2021) Molecular cell 81, 2013-2030.e9. PMID: 33773106 5. You, DJ. et al. (2015) Cellular signalling 27, 2173-81. PMID: 26296658
Note	For research use only

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Datasheet

Human ARFIP2 Recombinant Protein (N-His).pdf

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Human ARFIP2 Recombinant Protein (N-His) (HD593012)

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