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Anti-Human ARHGEF1 Polyclonal Antibody (HP865014)

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Vista general
Número de catálogoHP865014
Descripción
Anti-Human ARHGEF1 Polyclonal Antibody (HP865014) is a rabbit polyclonal antibody detecting ARHGEF1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ARHGEF1 (Ser39-Gly230).
Objetivo p115-RhoGEF, p115RhoGEF, 115 kDa guanine nucleotide exchange factor, Sub1.5, Rho guanine nucleotide exchange factor 1, ARHGEF1
Purificación Purified by antigen affinity column.
Número de acceso Q92888
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Rho guanine nucleotide exchange factor 1 (ARHGEF1) is a ~102 kDa protein. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

1. Kozasa, T. et al. (1998) Science (New York, N.Y.) 280, 2109-11. PMID: 9641915
2. Hart, MJ. et al. (1998) Science (New York, N.Y.) 280, 2112-4. PMID: 9641916
3. Bouafia, A. et al. (2019) The Journal of clinical investigation 129, 1047-1060. PMID: 30521495
4. Hart, MJ. et al. (1996) The Journal of biological chemistry 271, 25452-8. PMID: 8810315
5. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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