Anti-Human ARHGEF1 Polyclonal Antibody (HP865014)

Name: Anti-Human ARHGEF1 Polyclonal Antibody
Brand: abinScience
SKU: HP865014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HP865014

説明

Anti-Human ARHGEF1 Polyclonal Antibody (HP865014) is a rabbit polyclonal antibody detecting ARHGEF1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human ARHGEF1 (Ser39-Gly230).

ターゲット

p115-RhoGEF, p115RhoGEF, 115 kDa guanine nucleotide exchange factor, Sub1.5, Rho guanine nucleotide exchange factor 1, ARHGEF1

精製

Purified by antigen affinity column.

アクセッション番号

Q92888

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Rho guanine nucleotide exchange factor 1 (ARHGEF1) is a ~102 kDa protein. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

1. Kozasa, T. et al. (1998) Science (New York, N.Y.) 280, 2109-11. PMID: 9641915

2. Hart, MJ. et al. (1998) Science (New York, N.Y.) 280, 2112-4. PMID: 9641916

3. Bouafia, A. et al. (2019) The Journal of clinical investigation 129, 1047-1060. PMID: 30521495

4. Hart, MJ. et al. (1996) The Journal of biological chemistry 271, 25452-8. PMID: 8810315

5. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human ARHGEF1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human ARHGEF1 Polyclonal Antibody (HP865014)

概要

イメージ

参考文献

データシート

SDS