Anti-Human ARL3 Polyclonal Antibody (HW758014)

Name: Anti-Human ARL3 Polyclonal Antibody
Brand: abinScience
SKU: HW758014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
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概要

カタログ番号

HW758014

説明

Anti-Human ARL3 Polyclonal Antibody (HW758014) is a rabbit polyclonal antibody detecting ARL3 in ELISA, IHC, WB. Suitable for Bovine, Danio rerio, Human, Mouse, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human ARL3 (Met1-Lys182).

ターゲット

ARFL3, ADP-ribosylation factor-like protein 3, ARL3

精製

Purified by antigen affinity column.

アクセッション番号

P36405

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

ADP-ribosylation factor-like protein 3 (ARL3) is a ~20 kDa protein. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium.

1. Zhou, C. et al. (2006) Molecular biology of the cell 17, 2476-87. PMID: 16525022

2. Veltel, S. et al. (2008) FEBS letters 582, 2501-7. PMID: 18588884

3. Wright, KJ. et al. (2011) Genes & development 25, 2347-60. PMID: 22085962

4. Alkanderi, S. et al. (2018) American journal of human genetics 103, 612-620. PMID: 30269812

注意事項

For research use only.

イメージ

Western blot

Western blot analysis was performed using anti-ARL3 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Mouse heart lysate
Lane 2: Rat heart lysate

参考文献

データシート

Anti-Human ARL3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human ARL3 Polyclonal Antibody (HW758014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ