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| カタログ番号 | HP534014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ASF1A Polyclonal Antibody (HP534014) is a rabbit polyclonal antibody detecting ASF1A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ASF1A (Met1-His150). | ||||||||
| ターゲット | hAsf1, CCG1-interacting factor A, hAsf1a, Anti-silencing function protein 1 homolog A, Histone chaperone ASF1A, CIA, ASF1A, hCIA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y294 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Histone chaperone ASF1A is a ~22 kDa protein. Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. 1. Munakata, T. et al. (2000) Genes to cells : devoted to molecular & cellular mechanisms 5, 221-33. PMID: 10759893 2. Mello, JA. et al. (2002) EMBO reports 3, 329-34. PMID: 11897662 3. Umehara, T. et al. (2003) The Journal of biological chemistry 278, 35660-7. PMID: 12842904 4. Tagami, H. et al. (2004) Cell 116, 51-61. PMID: 14718166 5. Groth, A. et al. (2005) Molecular cell 17, 301-11. PMID: 15664198 6. Tamburini, BA. et al. (2005) Eukaryotic cell 4, 1583-90. PMID: 16151251 7. Alvarez, F. et al. (2011) The Journal of biological chemistry 286, 17714-21. PMID: 21454524 10. Zhang, R. et al. (2005) Developmental cell 8, 19-30. PMID: 15621527 | ||||||||
| 注意事項 | For research use only. |
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