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| カタログ番号 | HY187014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ASL Polyclonal Antibody (HY187014) is a rabbit polyclonal antibody detecting ASL in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ASL (Met1-Ala464). | ||||||||
| ターゲット | ASAL, Arginosuccinase, Argininosuccinate lyase, ASL | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P04424 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Argininosuccinate lyase (ASL) is a ~51 kDa protein. Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. 1. Sampaleanu, LM. et al. (2001) Biochemistry 40, 15570-80. PMID: 11747432 2. Yu, B. et al. (2001) Biochemistry 40, 15581-90. PMID: 11747433 3. Erez, A. et al. (2011) Nature medicine 17, 1619-26. PMID: 22081021 4. Walker, DC. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9625-9. PMID: 2263616 5. Walker, DC. et al. (1997) The Journal of biological chemistry 272, 6777-83. PMID: 9045711 | ||||||||
| 注意事項 | For research use only. |
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