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| カタログ番号 | HF566013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1961 | ||||
| ターゲット | Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O75787 | ||||
| RRID | Anti-Human ATP6AP2/Prorenin receptor Antibody (SAA1961) (abinScience Cat# HF566013, RRID:AB_3727725) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Renin receptor (ATP6AP2) is a ~39 kDa protein. Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. 1. Nguyen, G. et al. (2002) The Journal of clinical investigation 109, 1417-27. PMID: 12045255 2. Rujano, MA. et al. (2017) The Journal of experimental medicine 214, 3707-3729. PMID: 29127204 3. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053 4. Su, W. et al. (2020) Viruses 12. PMID: 32276428 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ATP6AP2/Prorenin receptor Antibody (SAA1961)
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