Anti-ATP6AP2 Polyclonal Antibody (HF566014)

Name: Anti-ATP6AP2 Polyclonal Antibody
Brand: abinScience
SKU: HF566014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HF566014

Description

Anti-ATP6AP2 Polyclonal Antibody (HF566014) is a rabbit polyclonal antibody detecting ATP6AP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ATP6AP2 (Asn17-Glu302).

Target

Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9

Purification

Purified by antigen affinity column.

Accession

O75787

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Renin receptor (ATP6AP2) is a ~39 kDa protein. Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.

1. Nguyen, G. et al. (2002) The Journal of clinical investigation 109, 1417-27. PMID: 12045255

2. Rujano, MA. et al. (2017) The Journal of experimental medicine 214, 3707-3729. PMID: 29127204

3. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053

4. Su, W. et al. (2020) Viruses 12. PMID: 32276428

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ATP6AP2 polyclonal antibody at 1ug/mL on recombinant ATP6AP2 (Catalog No. HF566012).

References

Datasheet

Anti-ATP6AP2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ATP6AP2 Polyclonal Antibody (HF566014)

Overview

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References

Datasheet

SDS

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