中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP667014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human B4GALNT2 Polyclonal Antibody (HP667014) is a rabbit polyclonal antibody detecting B4GALNT2. Suitable for Human.
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human B4GALNT2 (Thr324-Ala566). | ||||||||
| ターゲット | B4GALNT2, Beta-1,4 N-acetylgalactosaminyltransferase 2, EC:2.4.1.-, GALGT2, Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8NHY0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2) is a ~63 kDa protein. Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells. 1. Montiel, MD. et al. (2003) The Biochemical journal 373, 369-79. PMID: 12678917 2. Lo Presti, L. et al. (2003) Journal of biochemistry 134, 675-82. PMID: 14688233 3. Kawamura, YI. et al. (2005) Cancer research 65, 6220-7. PMID: 16024623 4. Stenfelt, L. et al. (2022) International journal of molecular sciences 23. PMID: 35409292 5. Heaton, BE. et al. (2017) Cell reports 20, 1503-1512. PMID: 28813663 | ||||||||
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
