Anti-Human BABAM2 Polyclonal Antibody (HP229014)

Name: Anti-Human BABAM2 Polyclonal Antibody
Brand: abinScience
SKU: HP229014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP229014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human BABAM2 (Met1-Leu383).

Objetivo

BRE, BRCA1/BRCA2-containing complex subunit 45, BRCA1-A complex subunit BRE, BRISC and BRCA1-A complex member 2, Brain and reproductive organ-expressed protein, BABAM2, BRCC45

Purificación

Purified by antigen affinity column.

Número de acceso

Q9NXR7

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

BRISC and BRCA1-A complex member 2 (BABAM2) is a ~43 kDa protein. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity.

1. Sobhian, B. et al. (2007) Science (New York, N.Y.) 316, 1198-202. PMID: 17525341

2. Shao, G. et al. (2009) Genes & development 23, 740-54. PMID: 19261746

3. Feng, L. et al. (2009) Genes & development 23, 719-28. PMID: 19261748

4. Wang, B. et al. (2009) Genes & development 23, 729-39. PMID: 19261749

5. Hu, X. et al. (2011) The Journal of biological chemistry 286, 11734-45. PMID: 21282113

6. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193

7. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

8. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

9. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human BABAM2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo