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| カタログ番号 | HP229014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BABAM2 (Met1-Leu383). | ||||||||
| ターゲット | BRE, BRCA1/BRCA2-containing complex subunit 45, BRCA1-A complex subunit BRE, BRISC and BRCA1-A complex member 2, Brain and reproductive organ-expressed protein, BABAM2, BRCC45 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NXR7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | BRISC and BRCA1-A complex member 2 (BABAM2) is a ~43 kDa protein. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. 1. Sobhian, B. et al. (2007) Science (New York, N.Y.) 316, 1198-202. PMID: 17525341 2. Shao, G. et al. (2009) Genes & development 23, 740-54. PMID: 19261746 3. Feng, L. et al. (2009) Genes & development 23, 719-28. PMID: 19261748 4. Wang, B. et al. (2009) Genes & development 23, 729-39. PMID: 19261749 5. Hu, X. et al. (2011) The Journal of biological chemistry 286, 11734-45. PMID: 21282113 6. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193 7. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 8. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148 9. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665 | ||||||||
| 注意事項 | For research use only. |
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