Anti-Human BAX Recombinant Antibody (2D9) (HC491063)

Name: Anti-Human BAX Recombinant Antibody (2D9)
Brand: abinScience
SKU: HC491063
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC491063

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a

ID de clon

2D9

Objetivo

BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q07812

RRID

Anti-Human BAX Antibody (2D9) (abinScience Cat# HC491063, RRID:AB_3729490)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Apoptosis regulator BAX is a ~21 kDa protein. Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

1. Schmitt, E. et al. (2000) Biochemical and biophysical research communications 270, 868-79. PMID: 10772918

2. Tan, KO. et al. (2001) The Journal of biological chemistry 276, 2802-7. PMID: 11060313

3. Zhang, H. et al. (2005) Nature cell biology 7, 909-15. PMID: 16113678

4. Tan, KO. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 14623-8. PMID: 16199525

5. Gavathiotis, E. et al. (2008) Nature 455, 1076-81. PMID: 18948948

6. Czabotar, PE. et al. (2011) The Journal of biological chemistry 286, 7123-31. PMID: 21199865

7. Edlich, F. et al. (2011) Cell 145, 104-16. PMID: 21458670

8. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812

9. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894

10. Oltvai, ZN. et al. (1993) Cell 74, 609-19. PMID: 8358790

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human BAX Antibody (2D9)

Referencias

Datasheet

Anti-Human BAX Recombinant Antibody (2D9).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo