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| カタログ番号 | HC491063 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | 2D9 | ||||
| ターゲット | BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q07812 | ||||
| RRID | Anti-Human BAX Antibody (2D9) (abinScience Cat# HC491063, RRID:AB_3729490) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Apoptosis regulator BAX is a ~21 kDa protein. Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. 1. Schmitt, E. et al. (2000) Biochemical and biophysical research communications 270, 868-79. PMID: 10772918 2. Tan, KO. et al. (2001) The Journal of biological chemistry 276, 2802-7. PMID: 11060313 3. Zhang, H. et al. (2005) Nature cell biology 7, 909-15. PMID: 16113678 4. Tan, KO. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 14623-8. PMID: 16199525 5. Gavathiotis, E. et al. (2008) Nature 455, 1076-81. PMID: 18948948 6. Czabotar, PE. et al. (2011) The Journal of biological chemistry 286, 7123-31. PMID: 21199865 7. Edlich, F. et al. (2011) Cell 145, 104-16. PMID: 21458670 8. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812 9. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894 10. Oltvai, ZN. et al. (1993) Cell 74, 609-19. PMID: 8358790 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human BAX Antibody (2D9)
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