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| カタログ番号 | HF603014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BCAS2 (Met1-Phe225). | ||||||||
| ターゲット | DNA amplified in mammary carcinoma 1 protein, BCAS2, DAM1, Breast carcinoma-amplified sequence 2, Pre-mRNA-splicing factor SPF27, Spliceosome-associated protein SPF 27 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75934 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Pre-mRNA-splicing factor SPF27 (BCAS2) is a ~26 kDa protein. Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). 1. Bertram, K. et al. (2017) Nature 542, 318-323. PMID: 28076346 2. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770 3. Zhan, X. et al. (2018) Science (New York, N.Y.) 359, 537-545. PMID: 29301961 4. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106 5. Fica, SM. et al. (2019) Science (New York, N.Y.) 363, 710-714. PMID: 30705154 | ||||||||
| 注意事項 | For research use only. |
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