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Anti-Human BEST1 Polyclonal Antibody (HC041014)

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Número de catálogoHC041014
Descripción
Anti-Human BEST1 Polyclonal Antibody (HC041014) is a rabbit polyclonal antibody detecting Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human BEST1 (Arg47-Asp70&Arg200-Asp228&Thr250-Asp270).
Objetivo Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O76090
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Bestrophin-1 (BEST1) is a ~67 kDa protein. Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Allows the movement of chloride and hydrogencarbonate. Found in a partially open conformation leading to significantly smaller chloride movement. Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition.

1. Sun, H. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4008-13. PMID: 11904445
2. Tsunenari, T. et al. (2003) The Journal of biological chemistry 278, 41114-25. PMID: 12907679
3. Burgess, R. et al. (2008) American journal of human genetics 82, 19-31. PMID: 18179881
4. Qu, Z. et al. (2008) American journal of physiology. Cell physiology 294, C1371-7. PMID: 18400985
5. Davidson, AE. et al. (2009) American journal of human genetics 85, 581-92. PMID: 19853238
6. Davidson, AE. et al. (2011) Investigative ophthalmology & visual science 52, 3730-6. PMID: 21330666
7. Johnson, AA. et al. (2015) Investigative ophthalmology & visual science 56, 4619-30. PMID: 26200502
8. Lee, CS. et al. (2015) Investigative ophthalmology & visual science 56, 8141-50. PMID: 26720466
9. Owji, AP. et al. (2022) Nature communications 13, 3836. PMID: 35789156
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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