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Anti-Human BEST1 Polyclonal Antibody (HC041014)

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Aperçu
Numéro de catalogueHC041014
Description
Anti-Human BEST1 Polyclonal Antibody (HC041014) is a rabbit polyclonal antibody detecting Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human BEST1 (Arg47-Asp70&Arg200-Asp228&Thr250-Asp270).
Cible Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O76090
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Bestrophin-1 (BEST1) is a ~67 kDa protein. Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Allows the movement of chloride and hydrogencarbonate. Found in a partially open conformation leading to significantly smaller chloride movement. Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition.

1. Sun, H. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4008-13. PMID: 11904445
2. Tsunenari, T. et al. (2003) The Journal of biological chemistry 278, 41114-25. PMID: 12907679
3. Burgess, R. et al. (2008) American journal of human genetics 82, 19-31. PMID: 18179881
4. Qu, Z. et al. (2008) American journal of physiology. Cell physiology 294, C1371-7. PMID: 18400985
5. Davidson, AE. et al. (2009) American journal of human genetics 85, 581-92. PMID: 19853238
6. Davidson, AE. et al. (2011) Investigative ophthalmology & visual science 52, 3730-6. PMID: 21330666
7. Johnson, AA. et al. (2015) Investigative ophthalmology & visual science 56, 4619-30. PMID: 26200502
8. Lee, CS. et al. (2015) Investigative ophthalmology & visual science 56, 8141-50. PMID: 26720466
9. Owji, AP. et al. (2022) Nature communications 13, 3836. PMID: 35789156
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human BEST1 Polyclonal Antibody

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