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| カタログ番号 | HC041014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human BEST1 Polyclonal Antibody (HC041014) is a rabbit polyclonal antibody detecting Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human BEST1 (Arg47-Asp70&Arg200-Asp228&Thr250-Asp270). | ||||||||
| ターゲット | Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O76090 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Bestrophin-1 (BEST1) is a ~67 kDa protein. Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Allows the movement of chloride and hydrogencarbonate. Found in a partially open conformation leading to significantly smaller chloride movement. Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition. 1. Sun, H. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4008-13. PMID: 11904445 2. Tsunenari, T. et al. (2003) The Journal of biological chemistry 278, 41114-25. PMID: 12907679 3. Burgess, R. et al. (2008) American journal of human genetics 82, 19-31. PMID: 18179881 4. Qu, Z. et al. (2008) American journal of physiology. Cell physiology 294, C1371-7. PMID: 18400985 5. Davidson, AE. et al. (2009) American journal of human genetics 85, 581-92. PMID: 19853238 6. Davidson, AE. et al. (2011) Investigative ophthalmology & visual science 52, 3730-6. PMID: 21330666 7. Johnson, AA. et al. (2015) Investigative ophthalmology & visual science 56, 4619-30. PMID: 26200502 8. Lee, CS. et al. (2015) Investigative ophthalmology & visual science 56, 8141-50. PMID: 26720466 9. Owji, AP. et al. (2022) Nature communications 13, 3836. PMID: 35789156 | ||||||||
| 注意事項 | For research use only |
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