Anti-Human BIRC7 Polyclonal Antibody (HP393014)

Name: Anti-Human BIRC7 Polyclonal Antibody
Brand: abinScience
SKU: HP393014
Price: 168 USD
Availability: InStock

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP393014

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human BIRC7 (Ser86-Ser176).

Cible

BIRC7, p30-Livin, Melanoma inhibitor of apoptosis protein, LIVIN, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Truncated livin, RNF50, KIAP, Livin, RING-type E3 ubiquitin transferase BIRC7, RING finger protein 50, tLivin, MLIAP, ML-IAP

Purification

Purified by antigen affinity column.

Numéro d'accès

Q96CA5

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Baculoviral IAP repeat-containing protein 7 (BIRC7) is a ~32 kDa protein. Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine.

1. Kasof, GM. et al. (2001) The Journal of biological chemistry 276, 3238-46. PMID: 11024045

2. Vucic, D. et al. (2000) Current biology : CB 10, 1359-66. PMID: 11084335

3. Lin, JH. et al. (2000) Biochemical and biophysical research communications 279, 820-31. PMID: 11162435

4. Ma, L. et al. (2006) Cell death and differentiation 13, 2079-88. PMID: 16729033

5. Nachmias, B. et al. (2007) Apoptosis : an international journal on programmed cell death 12, 1129-42. PMID: 17294084

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human BIRC7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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