Anti-Human BRD3 IP Recombinant Antibody (SAA0191) (HS898013)

Name: Anti-Human BRD3 IP Recombinant Antibody (SAA0191)
Brand: abinScience
SKU: HS898013
Price: 191 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HS898013

Reactivité des espèces

Human

Applications

ELISA, IF, IP

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a

ID de clone

SAA0191

Cible

BRD3, RING3-like protein, Bromodomain-containing protein 3, KIAA0043, RING3L

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q15059

RRID

Anti-Human BRD3 IP Antibody (SAA0191) (abinScience Cat# HS898013, RRID:AB_3729725)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Bromodomain-containing protein 3 (BRD3) is a ~79 kDa protein. Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4. Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression. Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.

1. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326

2. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331

3. Li, Y. et al. (2016) Molecular cell 62, 181-193. PMID: 27105114

4. Daneshvar, K. et al. (2020) Nature cell biology 22, 1211-1222. PMID: 32895492

5. Wai, DCC. et al. (2018) The Journal of biological chemistry 293, 7160-7175. PMID: 29567837

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human BRD3 IP Antibody (SAA0191)

Reférences

Fiche technique

Anti-Human BRD3 IP Recombinant Antibody (SAA0191).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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