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| カタログ番号 | HS898013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA0191 | ||||
| ターゲット | BRD3, RING3-like protein, Bromodomain-containing protein 3, KIAA0043, RING3L | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q15059 | ||||
| RRID | Anti-Human BRD3 IP Antibody (SAA0191) (abinScience Cat# HS898013, RRID:AB_3729725) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Bromodomain-containing protein 3 (BRD3) is a ~79 kDa protein. Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4. Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression. Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. 1. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326 2. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331 3. Li, Y. et al. (2016) Molecular cell 62, 181-193. PMID: 27105114 4. Daneshvar, K. et al. (2020) Nature cell biology 22, 1211-1222. PMID: 32895492 5. Wai, DCC. et al. (2018) The Journal of biological chemistry 293, 7160-7175. PMID: 29567837 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human BRD3 IP Antibody (SAA0191)
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