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Anti-Human CBX4 Polyclonal Antibody (HT334014)

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Número de catálogoHT334014
Descripción
Anti-Human CBX4 Polyclonal Antibody (HT334014) is a rabbit polyclonal antibody detecting CBX4. Suitable for Human.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CBX4 (Glu2-Gly73&Gly245-Gln275).
Objetivo CBX4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, EC:2.3.2.-, Pc2, Polycomb 2 homolog, hPc2
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O00257
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

E3 SUMO-protein ligase CBX4 is a ~61 kDa protein. E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate. Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain. Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation. Monosumoylates ZNF131.

1. Kagey, MH. et al. (2003) Cell 113, 127-37. PMID: 12679040
2. Oh, Y. et al. (2012) The Journal of biological chemistry 287, 17517-17529. PMID: 22467880
3. Pelisch, F. et al. (2012) The Journal of biological chemistry 287, 30789-99. PMID: 22825850
4. Levine, SS. et al. (2002) Molecular and cellular biology 22, 6070-8. PMID: 12167701
5. Maertens, GN. et al. (2009) PloS one 4, e6380. PMID: 19636380
6. Vandamme, J. et al. (2011) Molecular & cellular proteomics : MCP 10, M110.002642. PMID: 21282530
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human CBX4 Polyclonal Antibody

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