Anti-Human CBX5 Polyclonal Antibody (HW777014)

Name: Anti-Human CBX5 Polyclonal Antibody
Brand: abinScience
SKU: HW777014
Price: 96 USD
Availability: InStock

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Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW777014

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CBX5 (Gly2-Lys80).

Objetivo

Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, HP1A, Antigen p25, HP1 alpha, CBX5

Purificación

Purified by antigen affinity column.

Número de acceso

P45973

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Chromobox protein homolog 5 (CBX5) is a ~22 kDa protein. Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR).

1. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427

2. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980

3. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177

4. Kiyomitsu, T. et al. (2010) The Journal of cell biology 188, 791-807. PMID: 20231385

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-CBX5 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MCF-7 cell lysate
Lane 2: K562 cell lysate
Lane 3: PC-12 cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: A549 cell lysate