Human CBX5 Recombinant Protein (N-His) (HW777022)

Name: Human CBX5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW777022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW777022
Description	Recombinant Human CBX5 Protein, N-His (HW777022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P45973
Protein length	Tyr20-Ser191
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Antigen p25, CBX5, Chromobox protein homolog 5, HP1 alpha, HP1A, Heterochromatin protein 1 homolog alpha
Background	Chromobox protein homolog 5 is a ~22 kDa protein. Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). 1. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427 2. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980 3. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177 4. Kiyomitsu, T. et al. (2010) The Journal of cell biology 188, 791-807. PMID: 20231385
Note	For research use only