

| Numéro de catalogue | HY401013 | ||||
|---|---|---|---|---|---|
| Reactivité des espèces | Human | ||||
| Applications | ELISA | ||||
| Espèce hôte | Mouse | ||||
| Clonalité | Monoclonal | ||||
| Isotype | IgG1, kappa | ||||
| ID de clone | A1 | ||||
| Cible | Neprilysin, EC:3.4.24.11, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN | ||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||
| Pureté | >95% as determined by SDS-PAGE. | ||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||
| Numéro d'accès | P08473 | ||||
| Forme | Liquid | ||||
| Tampon de stockage | 0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Contexte | Neprilysin (CD10/MME) is a ~85 kDa protein. Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). 1. Rice, GI. et al. (2004) The Biochemical journal 383, 45-51. PMID: 15283675 2. Skidgel, RA. et al. (1984) Peptides 5, 769-76. PMID: 6208535 3. Gafford, JT. et al. (1983) Biochemistry 22, 3265-71. PMID: 6349683 4. Le Moual, H. et al. (1994) European journal of biochemistry 221, 475-80. PMID: 8168535 5. Wisner, A. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 17979-84. PMID: 17101991 6. Brandt, I. et al. (2006) Clinical chemistry 52, 82-7. PMID: 16254193 | ||||
| Note | For research use only | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |

SDS-PAGE for Anti-Human CD10/MME Antibody (A1)




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