Anti-Human IL-1 RI Recombinant Antibody (15C4), PerCP (HB791247)

Name: Anti-Human IL-1 RI Recombinant Antibody (15C4), PerCP
Brand: abinScience
SKU: HB791247
Price: 268 USD
Availability: InStock

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Каталожный номер	HB791247
Бренд	abinScience
Реактивность видов	Human, Monkey
Применения	ELISA, FCM, IF, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	15C4
Конъюгация	PerCP
Цель	IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PerCP
Номер доступа	P14778
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.