Anti-Human CD143/ACE Recombinant Antibody (9B9), APC (HY343137)

Name: Anti-Human CD143/ACE Recombinant Antibody (9B9), APC
Brand: abinScience
SKU: HY343137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HY343137
Reactivité des espèces	Human, Rat
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	9B9
Conjugaison	APC
Cible	Dipeptidyl carboxypeptidase I, DCP, CD143, Angiotensin-converting enzyme, DCP1, ACE, Kininase II
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Numéro d'accès	P12821
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Angiotensin-converting enzyme (CD143/ACE) is a ~149 kDa protein. Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins. 1. Naqvi, N. et al. (2005) The Journal of biological chemistry 280, 6669-75. PMID: 15615692 2. Anthony, CS. et al. (2010) The Journal of biological chemistry 285, 35685-93. PMID: 20826823 3. Takeuchi, K. et al. (1989) Journal of biochemistry 106, 442-5. PMID: 2558109 4. Yang, HY. et al. (1970) Biochimica et biophysica acta 214, 374-6. PMID: 4322742 5. Danilov, S. et al. (1994) The Journal of biological chemistry 269, 26806-14. PMID: 7523412 6. Jaspard, E. et al. (1993) The Journal of biological chemistry 268, 9496-503. PMID: 7683654 7. Araujo, MC. et al. (2000) Biochemistry 39, 8519-25. PMID: 10913258 8. Wei, L. et al. (1992) The Journal of biological chemistry 267, 13398-405. PMID: 1320019 9. Wei, L. et al. (1991) The Journal of biological chemistry 266, 9002-8. PMID: 1851160 10. Zou, K. et al. (2009) The Journal of biological chemistry 284, 31914-20. PMID: 19773553
Reférences	1. Wong MKS. Angiotensin Converting Enzymes. Handbook of Hormones. 2016:263–e29D-4. [HY343137]
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD143/ACE Recombinant Antibody (9B9), APC.pdf

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