Anti-Human CD143/ACE Recombinant Antibody (9B9) (HY343107)

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Catalog No.	HY343107
Description	Anti-Human CD143/ACE Antibody (9B9) [9B9] (HY343107) is a mouse monoclonal antibody detecting CD143 in ELISA, FCM, RIA. Suitable for Human and Rat. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human, Rat
Applications	ELISA, FCM, RIA
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	9B9
Clonality	Monoclonal
Target	Dipeptidyl carboxypeptidase I, DCP, CD143, Angiotensin-converting enzyme, DCP1, ACE, Kininase II
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P12821
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Angiotensin-converting enzyme (CD143/ACE) is a ~149 kDa protein. Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins. 1. Naqvi, N. et al. (2005) The Journal of biological chemistry 280, 6669-75. PMID: 15615692 2. Anthony, CS. et al. (2010) The Journal of biological chemistry 285, 35685-93. PMID: 20826823 3. Takeuchi, K. et al. (1989) Journal of biochemistry 106, 442-5. PMID: 2558109 4. Yang, HY. et al. (1970) Biochimica et biophysica acta 214, 374-6. PMID: 4322742 5. Danilov, S. et al. (1994) The Journal of biological chemistry 269, 26806-14. PMID: 7523412 6. Jaspard, E. et al. (1993) The Journal of biological chemistry 268, 9496-503. PMID: 7683654 7. Araujo, MC. et al. (2000) Biochemistry 39, 8519-25. PMID: 10913258 8. Wei, L. et al. (1992) The Journal of biological chemistry 267, 13398-405. PMID: 1320019 9. Wei, L. et al. (1991) The Journal of biological chemistry 266, 9002-8. PMID: 1851160 10. Zou, K. et al. (2009) The Journal of biological chemistry 284, 31914-20. PMID: 19773553
Note	For research use only.

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Anti-Human CD143/ACE Recombinant Antibody (9B9).pdf

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Anti-Human CD143/ACE Recombinant Antibody (9B9) (HY343107)

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