中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY343137 |
|---|---|
| 種反応性 | Human, Rat |
| アプリケーション | ELISA, FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 9B9 |
| 抱合 | APC |
| ターゲット | Dipeptidyl carboxypeptidase I, DCP, CD143, Angiotensin-converting enzyme, DCP1, ACE, Kininase II |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| アクセッション番号 | P12821 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Angiotensin-converting enzyme (CD143/ACE) is a ~149 kDa protein. Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins. 1. Naqvi, N. et al. (2005) The Journal of biological chemistry 280, 6669-75. PMID: 15615692 2. Anthony, CS. et al. (2010) The Journal of biological chemistry 285, 35685-93. PMID: 20826823 3. Takeuchi, K. et al. (1989) Journal of biochemistry 106, 442-5. PMID: 2558109 4. Yang, HY. et al. (1970) Biochimica et biophysica acta 214, 374-6. PMID: 4322742 5. Danilov, S. et al. (1994) The Journal of biological chemistry 269, 26806-14. PMID: 7523412 6. Jaspard, E. et al. (1993) The Journal of biological chemistry 268, 9496-503. PMID: 7683654 7. Araujo, MC. et al. (2000) Biochemistry 39, 8519-25. PMID: 10913258 8. Wei, L. et al. (1992) The Journal of biological chemistry 267, 13398-405. PMID: 1320019 9. Wei, L. et al. (1991) The Journal of biological chemistry 266, 9002-8. PMID: 1851160 10. Zou, K. et al. (2009) The Journal of biological chemistry 284, 31914-20. PMID: 19773553 |
| 参考文献 | 1. Wong MKS. Angiotensin Converting Enzymes. Handbook of Hormones. 2016:263–e29D-4. [HY343137] |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
