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| カタログ番号 | HY343013 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | SAA2704 |
| ターゲット | ACE, Angiotensin-converting enzyme, Angiotensin-converting enzyme, soluble form, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, EC:3.4.15.1, Kininase II |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P12821 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Angiotensin-converting enzyme (CD143/ACE) is a ~149 kDa protein. Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins. 1. Naqvi, N. et al. (2005) The Journal of biological chemistry 280, 6669-75. PMID: 15615692 2. Anthony, CS. et al. (2010) The Journal of biological chemistry 285, 35685-93. PMID: 20826823 3. Takeuchi, K. et al. (1989) Journal of biochemistry 106, 442-5. PMID: 2558109 4. Yang, HY. et al. (1970) Biochimica et biophysica acta 214, 374-6. PMID: 4322742 5. Danilov, S. et al. (1994) The Journal of biological chemistry 269, 26806-14. PMID: 7523412 6. Jaspard, E. et al. (1993) The Journal of biological chemistry 268, 9496-503. PMID: 7683654 7. Araujo, MC. et al. (2000) Biochemistry 39, 8519-25. PMID: 10913258 8. Wei, L. et al. (1992) The Journal of biological chemistry 267, 13398-405. PMID: 1320019 9. Wei, L. et al. (1991) The Journal of biological chemistry 266, 9002-8. PMID: 1851160 10. Zou, K. et al. (2009) The Journal of biological chemistry 284, 31914-20. PMID: 19773553 |
| 注意事項 | For research use only |
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