Anti-Human CD151 Recombinant Antibody (TS151), APC (HW567137)

Name: Anti-Human CD151 Recombinant Antibody (TS151), APC
Brand: abinScience
SKU: HW567137
Price: 290 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HW567137
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	TS151
抱合	APC
ターゲット	CD151, PETA-3, Membrane glycoprotein SFA-1, GP27, Tspan-24, Platelet-endothelial tetraspan antigen 3, CD151 antigen, Tetraspanin-24, TSPAN24
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
アクセッション番号	P48509
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	CD151 antigen is a ~28 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. 1. Zheng, ZZ. et al. (2007) The international journal of biochemistry & cell biology 39, 340-8. PMID: 17045834 2. Rocha-Perugini, V. et al. (2014) European journal of immunology 44, 1967-75. PMID: 24723389 3. Te Molder, L. et al. (2019) Journal of cell science 132. PMID: 31488507 4. Hong, IK. et al. (2012) The Journal of biological chemistry 287, 32027-39. PMID: 22843693 5. Thölmann, S. et al. (2022) Cellular and molecular life sciences : CMLS 79, 88. PMID: 35067832 6. Baldwin, G. et al. (2008) The Journal of biological chemistry 283, 35445-54. PMID: 18852263 7. Karamatic Crew, V. et al. (2004) Blood 104, 2217-23. PMID: 15265795
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

イメージ

Flow CytoMetry

Flow-cytometry using APC anti-human CD151 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD151 monoclonal antibody (Catalog: HW567137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

参考文献

データシート