Anti-Human CD151 Recombinant Antibody (TS151) (HW567107)

Name: Anti-Human CD151 Recombinant Antibody (TS151)
Brand: abinScience
SKU: HW567107
Price: 191 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.	HW567107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	TS151
Clonality	Monoclonal
Target	CD151, PETA-3, Membrane glycoprotein SFA-1, GP27, Tspan-24, Platelet-endothelial tetraspan antigen 3, CD151 antigen, Tetraspanin-24, TSPAN24
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P48509
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	CD151 antigen is a ~28 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. 1. Zheng, ZZ. et al. (2007) The international journal of biochemistry & cell biology 39, 340-8. PMID: 17045834 2. Rocha-Perugini, V. et al. (2014) European journal of immunology 44, 1967-75. PMID: 24723389 3. Te Molder, L. et al. (2019) Journal of cell science 132. PMID: 31488507 4. Hong, IK. et al. (2012) The Journal of biological chemistry 287, 32027-39. PMID: 22843693 5. Thölmann, S. et al. (2022) Cellular and molecular life sciences : CMLS 79, 88. PMID: 35067832 6. Baldwin, G. et al. (2008) The Journal of biological chemistry 283, 35445-54. PMID: 18852263 7. Karamatic Crew, V. et al. (2004) Blood 104, 2217-23. PMID: 15265795
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human CD151 Antibody (TS151).
Flow Cytometry

Flow-cytometry using anti-human CD151 antibody.Human peripheral blood lymphocytes were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD151 antibody monoclonal antibody (Catalog # HW567107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.