Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3), APC (HX200137)

Name: Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3), APC
Brand: abinScience
SKU: HX200137
Price: 290 USD
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Número de catálogo	HX200137
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	1022C3
Conjugación	APC
Objetivo	TACE, Snake venom-like protease, ADAM17, CD156b, CSVP, ADAM 17, Disintegrin and metalloproteinase domain-containing protein 17, TNF-alpha convertase, TNF-alpha-converting enzyme
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Número de acceso	P78536
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). 1. Boskovski, MT. et al. (2013) Nature 504, 456-9. PMID: 24226769 2. Heurich, A. et al. (2014) Journal of virology 88, 1293-307. PMID: 24227843 3. Riethmueller, S. et al. (2017) PLoS biology 15, e2000080. PMID: 28060820 4. Feuerbach, D. et al. (2017) Neuroscience letters 660, 109-114. PMID: 28923481 5. Müller, M. et al. (2022) Cells 11. PMID: 36078095 6. Moss, ML. et al. (1997) Nature 385, 733-6. PMID: 9034191 7. Rabquer, BJ. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 1777-85. PMID: 20592283 8. Thathiah, A. et al. (2003) The Journal of biological chemistry 278, 3386-94. PMID: 12441351
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.