Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3), APC (HX200137)

Name: Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3), APC
Brand: abinScience
SKU: HX200137
Price: 290 USD
Availability: InStock

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Каталожный номер	HX200137
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	1022C3
Конъюгация	APC
Цель	TACE, Snake venom-like protease, ADAM17, CD156b, CSVP, ADAM 17, Disintegrin and metalloproteinase domain-containing protein 17, TNF-alpha convertase, TNF-alpha-converting enzyme
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Номер доступа	P78536
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). 1. Boskovski, MT. et al. (2013) Nature 504, 456-9. PMID: 24226769 2. Heurich, A. et al. (2014) Journal of virology 88, 1293-307. PMID: 24227843 3. Riethmueller, S. et al. (2017) PLoS biology 15, e2000080. PMID: 28060820 4. Feuerbach, D. et al. (2017) Neuroscience letters 660, 109-114. PMID: 28923481 5. Müller, M. et al. (2022) Cells 11. PMID: 36078095 6. Moss, ML. et al. (1997) Nature 385, 733-6. PMID: 9034191 7. Rabquer, BJ. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 1777-85. PMID: 20592283 8. Thathiah, A. et al. (2003) The Journal of biological chemistry 278, 3386-94. PMID: 12441351
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.