Anti-Human CD160 Reference Antibody (H7) (HF985107)

Name: Anti-Human CD160 Reference Antibody (H7)
Brand: abinScience
SKU: HF985107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	HF985107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	H7
Objetivo	Natural killer cell receptor BY55, CD160 antigen, CD160, BY55
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O95971
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	CD160 antigen is a ~19 kDa protein. Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. 1. Nikolova, M. et al. (2002) International immunology 14, 445-51. PMID: 11978774 2. Rabot, M. et al. (2007) International immunology 19, 401-9. PMID: 17307798 3. Giustiniani, J. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 63-71. PMID: 19109136 4. Le Bouteiller, P. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16963-8. PMID: 12486241 5. Agrawal, S. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 162, 1223-6. PMID: 9973372 6. Viganò, S. et al. (2014) PLoS pathogens 10, e1004380. PMID: 25255144 7. Fons, P. et al. (2006) Blood 108, 2608-15. PMID: 16809620 8. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050
Nota	For research use only.

Imágenes

Bioactivity

Detects Human CD160 in indirect ELISAs.
Flow-cytometry

Flow-cytometry using anti-human CD160 antibody.CD160 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD160 antibody monoclonal antibody (Catalog # HF985107 ,Green Histogram) at a concentration of 5 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.