Anti-Human CD161 Recombinant Antibody (KM12.4.7) (HC598107)

Name: Anti-Human CD161 Recombinant Antibody (KM12.4.7)
Brand: abinScience
SKU: HC598107
Price: 163 USD
Availability: InStock

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Vista general

Número de catálogo	HC598107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	KM12.4.7
Aplicaciones probadas	WB
Objetivo	CLEC5B, KLRB1, CD161, HNKR-P1a, C-type lectin domain family 5 member B, NKRP1A, Natural killer cell surface protein P1A, Killer cell lectin-like receptor subfamily B member 1, NKR-P1A
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q12918
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Killer cell lectin-like receptor subfamily B member 1 (CD161/KLRB1) is a ~25 kDa protein. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Referencias	1. Zhao Y, et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901. [HC598107]
Nota	For research use only.

Imágenes

Bioactivity

Detects Human CD161/KLRB1 in indirect ELISAs.
Bioactivity

SEC-HPLC detection for Anti-Human CD161/KLRB1/NK1.1 Antibody (KM12.4.7).
Western blot

Western blot analysis was performed using anti-CD161/KLRB1 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD161/KLRB1 (Catalog No: HC598011)

Referencias

Datasheet

Anti-Human CD161 Recombinant Antibody (KM12.4.7).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Proteínas Recombinantes

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