Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO) (HC598016)

Name: Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO)
Brand: abinScience
SKU: HC598016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HC598016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Biological activity	CD161 has K i s of 8.2 nM and 1.4 nM for BRD4 BD1 and BRD4 BD2, respectively [1]. CD161 (30-3000 nM; 1 hours) is very effective in inducing rapid down-regulation of c-Myc at as early as the 1 h time point and in a dose-dependent manner [1]. Western Blot Analysis [1] Cell Line: MV4;11 leukemia cells. Concentration: 30, 100, 300, 1000, 3000 nM Incubation Time: 1 hours Result: Induced rapid down-regulation of c-Myc at as early as the 1 hours time point and in a dose-dependent manner. CD161 (po; 20, 40 mg/kg/day; 45 days) achieves essentially complete tumor growth inhibition [1]. CD161 (5 mg/kg (iv), 25 mg/kg (po); 0-24 hours) has the t 1/2 of 2.4 hours (iv) and 2.9 hours (po) for rat; the C max of 7333 ng/mL (po) for rat. The t 1/2 of mice is 0.5 hours (iv) and 1.60 hours (po); the C max of mice is 983.1 ng/mL (po) [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CLEC5B, KLRB1, CD161, HNKR-P1a, C-type lectin domain family 5 member B, NKRP1A, Natural killer cell surface protein P1A, Killer cell lectin-like receptor subfamily B member 1, NKR-P1A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q12918
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2762201-86-3
Background	Killer cell lectin-like receptor subfamily B member 1 (CD161/KLRB1) is a ~25 kDa protein. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
References	1. Zhao Y, et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901. [HC598016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Rezorstobart
Bioactivity

Detects recombinant human CD161 (Catalog No: HC598021) in indirect ELISA

References

Datasheet

Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO).pdf

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Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO) (HC598016)

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References

Datasheet

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