Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO) (HC598016)

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1mg

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Overview

Catalog No.	HC598016
Description	Rezorstobart (HC598016) is a research-grade recombinant antibody targeting CD161. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	CLEC5B, KLRB1, CD161, HNKR-P1a, C-type lectin domain family 5 member B, NKRP1A, Natural killer cell surface protein P1A, Killer cell lectin-like receptor subfamily B member 1, NKR-P1A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q12918
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2762201-86-3
Background	Killer cell lectin-like receptor subfamily B member 1 (CD161/KLRB1) is a ~25 kDa protein. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Rezorstobart
Bioactivity

Detects recombinant human CD161 (Catalog No: HC598021) in indirect ELISA

References

Datasheet

Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO).pdf

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Recombinant Proteins

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Anti-Human Fc gamma RIIIA/CD16a1 Reference Antibody (Rezorstobart, RUO) (HC598016)

Overview

Images

References

Datasheet

SDS

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