Anti-Human Fc gamma RIIIA/CD16a1/KLRB1/NK1.1 Recombinant Antibody (KM12.4.7) (HC598107)

Name: Anti-Human Fc gamma RIIIA/CD16a1/KLRB1/NK1.1 Recombinant Antibody (KM12.4.7)
Brand: abinScience
SKU: HC598107
Price: 163 USD
Availability: InStock

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Overview

Catalog No.	HC598107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	KM12.4.7
Clonality	Monoclonal
Target	CLEC5B, KLRB1, CD161, HNKR-P1a, C-type lectin domain family 5 member B, NKRP1A, Natural killer cell surface protein P1A, Killer cell lectin-like receptor subfamily B member 1, NKR-P1A
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q12918
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Killer cell lectin-like receptor subfamily B member 1 (CD161/KLRB1) is a ~25 kDa protein. Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
References	1. Zhao Y, et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901. [HC598107]
Note	For research use only.

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Bioactivity

Detects Human CD161/KLRB1 in indirect ELISAs.
Bioactivity

SEC-HPLC detection for Anti-Human CD161/KLRB1/NK1.1 Antibody (KM12.4.7).
Western blot

Western blot analysis was performed using anti-CD161/KLRB1 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD161/KLRB1 (Catalog No: HC598011)

References

Datasheet

Anti-Human Fc gamma RIIIA/CD16a1/KLRB1/NK1.1 Recombinant Antibody (KM12.4.7).pdf

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Recombinant Proteins

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Anti-Human Fc gamma RIIIA/CD16a1/KLRB1/NK1.1 Recombinant Antibody (KM12.4.7) (HC598107)

Overview

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Datasheet

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