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| カタログ番号 | HY386207 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | NM3E2 |
| ターゲット | CD16a, CD16A, FCGR3A, Fc-gamma RIII-alpha, FcRIIIa, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A, IGFR3, CD16a antigen, Fc-gamma RIII, FCGR3, Fc-gamma RIIIa, FCG3, FcRIII, FcR-10 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P08637 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.09% Sodium azide. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a/FCGR3A) is a ~29 kDa protein. Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. 1. Hezareh, M. et al. (2001) Journal of virology 75, 12161-8. PMID: 11711607 2. Ferrara, C. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12669-74. PMID: 21768335 3. Mizushima, T. et al. (2011) Genes to cells : devoted to molecular & cellular mechanisms 16, 1071-80. PMID: 22023369 4. DiLillo, DJ. et al. (2014) Nature medicine 20, 143-51. PMID: 24412922 5. Lee, J. et al. (2015) Immunity 42, 431-42. PMID: 25786175 6. Jing, Y. et al. (2015) PloS one 10, e0121788. PMID: 25816339 7. Blázquez-Moreno, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E5645-E5654. PMID: 28652325 8. de Haas, M. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 2948-55. PMID: 8609432 9. Koene, HR. et al. (1997) Blood 90, 1109-14. PMID: 9242542 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD16a/FCGR3A Antibody (NM3E2)
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