Anti-Human Fc gamma RIII/CD16 Recombinant Antibody (NM3E2), PE (HY386227)

Name: Anti-Human Fc gamma RIII/CD16 Recombinant Antibody (NM3E2), PE
Brand: abinScience
SKU: HY386227
Price: 256 USD
Availability: InStock

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Numéro de catalogue	HY386227
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	NM3E2
Conjugaison	PE
Cible	CD16a, CD16A, FCGR3A, Fc-gamma RIII-alpha, FcRIIIa, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A, IGFR3, CD16a antigen, Fc-gamma RIII, FCGR3, Fc-gamma RIIIa, FCG3, FcRIII, FcR-10
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Numéro d'accès	P08637
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a/FCGR3A) is a ~29 kDa protein. Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. 1. Hezareh, M. et al. (2001) Journal of virology 75, 12161-8. PMID: 11711607 2. Ferrara, C. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12669-74. PMID: 21768335 3. Mizushima, T. et al. (2011) Genes to cells : devoted to molecular & cellular mechanisms 16, 1071-80. PMID: 22023369 4. DiLillo, DJ. et al. (2014) Nature medicine 20, 143-51. PMID: 24412922 5. Lee, J. et al. (2015) Immunity 42, 431-42. PMID: 25786175 6. Jing, Y. et al. (2015) PloS one 10, e0121788. PMID: 25816339 7. Blázquez-Moreno, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E5645-E5654. PMID: 28652325 8. de Haas, M. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 2948-55. PMID: 8609432 9. Koene, HR. et al. (1997) Blood 90, 1109-14. PMID: 9242542
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.