Anti-Human Fc gamma RIIIA/CD16a Recombinant Nanobody (SAA2051) (HY386013)

Name: Anti-Human Fc gamma RIIIA/CD16a Recombinant Nanobody (SAA2051)
Brand: abinScience
SKU: HY386013
Price: 126 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HY386013

Marque

abinScience

Description

Anti-Human CD16a/FCGR3A Nanobody (SAA2051) [SAA2051] (HY386013) is a alpaca monoclonal antibody detecting FCGR3A in ELISA, FCM. Suitable for Human and Cynomolgus.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Reactivité des espèces

Human, Monkey

Applications

ELISA, FCM

Espèce hôte

Alpaca

Clonalité

Monoclonal

Isotype

VHH-8His-Cys-tag

ID de clone

SAA2051

Cible

CD16a, CD16A, FCGR3A, Fc-gamma RIII-alpha, FcRIIIa, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A, IGFR3, CD16a antigen, Fc-gamma RIII, FCGR3, Fc-gamma RIIIa, FCG3, FcRIII, FcR-10

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Numéro d'accès

P08637

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a/FCGR3A) is a ~29 kDa protein. Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.

1. Hezareh, M. et al. (2001) Journal of virology 75, 12161-8. PMID: 11711607

2. Ferrara, C. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12669-74. PMID: 21768335

3. Mizushima, T. et al. (2011) Genes to cells : devoted to molecular & cellular mechanisms 16, 1071-80. PMID: 22023369

4. DiLillo, DJ. et al. (2014) Nature medicine 20, 143-51. PMID: 24412922

5. Lee, J. et al. (2015) Immunity 42, 431-42. PMID: 25786175

6. Jing, Y. et al. (2015) PloS one 10, e0121788. PMID: 25816339

7. Blázquez-Moreno, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E5645-E5654. PMID: 28652325

8. de Haas, M. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 2948-55. PMID: 8609432

9. Koene, HR. et al. (1997) Blood 90, 1109-14. PMID: 9242542

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD16a/FCGR3A Nanobody (SAA2051)

Reférences

Fiche technique

Anti-Human Fc gamma RIIIA/CD16a Recombinant Nanobody (SAA2051).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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