Anti-Human Integrin beta 2/CD18 Recombinant Antibody (SAA2180), APC (HY378237)

Name: Anti-Human Integrin beta 2/CD18 Recombinant Antibody (SAA2180), APC
Brand: abinScience
SKU: HY378237
Price: 256 USD
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Número de catálogo	HY378237
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	SAA2180
Conjugación	APC
Objetivo	CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, ITGB2, Integrin beta-2, MFI7
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Normal Human IgG Isotype Control Antibody, APC
Número de acceso	P05107
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048 2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055 5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935 6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714 7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932 8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110 9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.