Anti-Human Integrin beta 2/CD18 Recombinant Antibody (SAA2180), APC (HY378237)

Name: Anti-Human Integrin beta 2/CD18 Recombinant Antibody (SAA2180), APC
Brand: abinScience
SKU: HY378237
Price: 256 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HY378237
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	SAA2180
抱合	APC
ターゲット	CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, ITGB2, Integrin beta-2, MFI7
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
関連製品	Normal Human IgG Isotype Control Antibody, APC
アクセッション番号	P05107
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048 2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055 5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935 6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714 7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932 8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110 9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.