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| カタログ番号 | HB896013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, FCM, Neutralization | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA2405 | ||||
| ターゲット | C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P32246 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | C-C chemokine receptor type 1 (CD191/CCR1) is a ~41 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. 1. Tian, Y. et al. (2004) European journal of immunology 34, 785-795. PMID: 14991608 2. Berahovich, RD. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7341-51. PMID: 15905581 3. Wei, H. et al. (2024) Cellular signalling 117, 111122. PMID: 38417634 4. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254 | ||||
| 注意事項 | For research use only |
SDS-PAGE for Anti-Human CD191/CCR1 Antibody (SAA2405)
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