Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), APC (HW620137)

Name: Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), APC
Brand: abinScience
SKU: HW620137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HW620137
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2b, kappa
ID de clone	5E8-G9-B4
Conjugaison	APC
Cible	CCR-3, C-C chemokine receptor type 3, CKR3, CC-CKR-3, C-C CKR-3, CKR 3, CCR3, CMKBR3, CD193, C C CKR3, Eosinophil eotaxin receptor
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2b, kappa Recombinant Isotype Control Antibody (MPC-11), APC
Numéro d'accès	P51677
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	C-C chemokine receptor type 3 (CD193/CCR3) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. 1. Song, Y. et al. (2018) Biochemistry 57, 852-860. PMID: 28994588 2. Combadiere, C. et al. (1995) The Journal of biological chemistry 270, 16491-4. PMID: 7622448 3. Daugherty, BL. et al. (1996) The Journal of experimental medicine 183, 2349-54. PMID: 8642344 4. Ponath, PD. et al. (1996) The Journal of experimental medicine 183, 2437-48. PMID: 8676064 5. Tian, Y. et al. (2008) Cellular signalling 20, 1179-89. PMID: 18406577 6. Shao, Z. et al. (2022) Cell discovery 8, 44. PMID: 35570218 7. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), APC.pdf

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