Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4) (HW620107)

Name: Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4)
Brand: abinScience
SKU: HW620107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW620107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG2b, kappa
Clone ID	5E8-G9-B4
Clonality	Monoclonal
Target	CCR-3, C-C chemokine receptor type 3, CKR3, CC-CKR-3, C-C CKR-3, CKR 3, CCR3, CMKBR3, CD193, C C CKR3, Eosinophil eotaxin receptor
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P51677
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	C-C chemokine receptor type 3 (CD193/CCR3) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. 1. Song, Y. et al. (2018) Biochemistry 57, 852-860. PMID: 28994588 2. Combadiere, C. et al. (1995) The Journal of biological chemistry 270, 16491-4. PMID: 7622448 3. Daugherty, BL. et al. (1996) The Journal of experimental medicine 183, 2349-54. PMID: 8642344 4. Ponath, PD. et al. (1996) The Journal of experimental medicine 183, 2437-48. PMID: 8676064 5. Tian, Y. et al. (2008) Cellular signalling 20, 1179-89. PMID: 18406577 6. Shao, Z. et al. (2022) Cell discovery 8, 44. PMID: 35570218 7. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human CD193/CCR3 Antibody (5E8-G9-B4).
Flow CytoMetry

Flow-cytometry using anti-human CD193 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD193 monoclonal antibody (Catalog: HW620107) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.

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Datasheet

Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4).pdf

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Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4) (HW620107)

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