Anti-Human CD21/CR2 Recombinant Antibody (HB5), FITC (HB939117)

Name: Anti-Human CD21/CR2 Recombinant Antibody (HB5), FITC
Brand: abinScience
SKU: HB939117
Price: 118 USD
Availability: InStock

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Numéro de catalogue	HB939117
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	HB5
Conjugaison	FITC
Applications testées	FCM
Cible	Cr2, Complement C3d receptor, C3DR, Epstein-Barr virus receptor, Complement receptor type 2, CR2, EBV receptor, CD21
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), FITC
Numéro d'accès	P20023
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. 1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076 2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715 3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047 4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329 5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486 6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232 7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow Cytometry

Flow-cytometry using FITC anti-human CD21 antibody. Raji cells were stained with an irrelevant antibody (Green Histogram) or a FITC anti-human CD21 antibody monoclonal antibody (Catalog # HB939117, Red Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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