Anti-Human MDR1/ABCB1 Recombinant Antibody (C219), APC (HY466137)

Name: Anti-Human MDR1/ABCB1 Recombinant Antibody (C219), APC
Brand: abinScience
SKU: HY466137
Price: 290 USD
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Número de catálogo	HY466137
Reactividad de especies	Human
Aplicaciones	FCM, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	C219
Conjugación	APC
Objetivo	Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1, P-Glycoprotein, P Glycoprotein
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Número de acceso	P08183
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	ATP-dependent translocase ABCB1 (CD243) is a ~141 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. 1. Choi, KH. et al. (1988) Cell 53, 519-29. PMID: 2897240 2. Masud, SN. et al. (2022) Nature chemical biology 18, 1370-1379. PMID: 35970996 3. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203 4. Chen, G. et al. (1997) The Journal of biological chemistry 272, 5974-82. PMID: 9038218 5. Shafik, SH. et al. (2022) PLoS biology 20, e3001616. PMID: 35507548
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.