

| Каталожный номер | HY466337 |
|---|---|
| Реактивность видов | Human |
| Применения | FCM |
| Хозяинский вид | Mouse |
| Клоональность | Monoclonal |
| Изотип | IgG1, kappa |
| ID клона | MRK16 |
| Конъюгация | APC |
| Цель | Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1, P-Glycoprotein, P Glycoprotein |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Связанные продукты | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| Номер доступа | P08183 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Фон | ATP-dependent translocase ABCB1 (CD243) is a ~141 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. 1. Choi, KH. et al. (1988) Cell 53, 519-29. PMID: 2897240 2. Masud, SN. et al. (2022) Nature chemical biology 18, 1370-1379. PMID: 35970996 3. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203 4. Chen, G. et al. (1997) The Journal of biological chemistry 272, 5974-82. PMID: 9038218 5. Shafik, SH. et al. (2022) PLoS biology 20, e3001616. PMID: 35507548 |
| Примечание | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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