Anti-Human CD288/TLR8 Polyclonal Antibody (HV511014)

Name: Anti-Human CD288/TLR8 Polyclonal Antibody
Brand: abinScience
SKU: HV511014
Price: 168 USD
Availability: InStock

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV511014

Descripción

Anti-Human CD288/TLR8 Polyclonal Antibody (HV511014) is a rabbit polyclonal antibody detecting CD288/TLR8 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD288/TLR8 (Glu27-Ile140).

Objetivo

Toll-like receptor 8, CD288, TLR8

Purificación

Purified by antigen affinity column.

Número de acceso

Q9NR97

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Toll-like receptor 8 (CD288/TLR8) is a ~119 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.

1. Ishii, N. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5118-28. PMID: 25297876

2. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612

3. Greulich, W. et al. (2019) Cell 179, 1264-1275.e13. PMID: 31778653

4. Campbell, GR. et al. (2021) iScience 24, 102295. PMID: 33718825

5. Tanji, H. et al. (2013) Science (New York, N.Y.) 339, 1426-9. PMID: 23520111

6. Tanji, H. et al. (2015) Nature structural & molecular biology 22, 109-15. PMID: 25599397

7. Tanji, H. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3012-7. PMID: 26929371

8. Qin, J. et al. (2006) The Journal of biological chemistry 281, 21013-21021. PMID: 16737960

9. Doyle, SL. et al. (2007) The Journal of biological chemistry 282, 36953-60. PMID: 17932028

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human CD288/TLR8 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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